Title:

Direct Impact of Pomegranate Juice and Peel Extracts on Prostate Cancer Progression – Inhibition of Proliferation, Migration, and Colony Formation in Prostate Cancer Cell Lines

Author:

Tingwei Li

Hangzhou Dianzi University, China

Received: 24^th Aug, 2025; Revised: 11^th Sep 2025; Accepted: 17^th Nov, 2025; Available Online: 1^st December, 2025

ABSTRACT

Prostate cancer, which affects millions of men worldwide, is a prevalent form of cancer. The risk factors associated with it include age, genetics, and diet. Despite advances in cancer research, the quest for effective treatments and preventive measures against this disease remains an ongoing challenge. Pomegranate, a fruit known for its antioxidant-rich juice and bioactive peel extracts, has been identified as a prospective therapeutic intervention for a range of health ailments, including cancer. The current study set out to look at the direct effects of the juice of pomegranates and peel extract on the advancement of prostate cancer. We evaluated their capacity to impede prostate cancer cell lines’ colony formation, motility, and proliferation as cancer cells. To achieve this, the MTT test was used to measure the drop in the survival of cells that followed a PP extract injection. Prostate cancer cells’ ability to form colonies and their ability to be inhibited from migrating were also evaluated using the clonogenic assay and wound healing experiment conducted with the help of pomegranate extracts. The results revealed promising inhibitory effects of pomegranate extracts on these key cancer hallmarks, suggesting their potential as complementary therapeutic agents for prostate cancer.

Keywords: Natural extracts, Anticancer, Antioxidants, Pomegranate, Cytotoxicity

How to cite this article: Li T, Direct Impact of Pomegranate Juice and Peel Extracts on Prostate Cancer Progression – Inhibition of Proliferation, Migration, and Colony Formation in Prostate Cancer Cell Lines. Int J Drug Deliv Technol. 2026;16(1): 453-459

Source of support: Nil.

Conflict of interest: None

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