Title:

LC–HRMS, Molecular Docking, and ADMET-Based Evaluation of Qurs-E-Ziabetus Khas for Antidiabetic Potential

Author:

Kamati Mounika¹, P. Dharani Prasad¹*

1Department of Pharmacology, School of Pharmaceutical Sciences (Erstwhile Sree Vidyaniketan College of Pharmacy), Mohan Babu University, Tirupati 517102, Andra Pradesh, India

Received: 14^th Aug, 2025; Revised: 15^th Sep 2025; Accepted: 18^th Nov, 2025; Available Online: 1^st December, 2025

ABSTRACT

Qurs-e-Ziabetus Khas (QZKH) is an Unani polyherbal-mineral formulation used for the management of diabetes mellitus (Ziabetus Shakri). This study used to analyze its phytochemical, physicochemical, pharmacological, and molecular attributes to scientifically establish its therapeutic effectiveness. Physicochemical and organoleptic tests showed that QZKH tablets are smooth, and compact, with a pH of 6.2 to 6.9, a low moisture content of 4.1%, and no microbiological or heavy metal contamination. This indicates that the product is good quality as well as safe. Phytochemical analysis revealed the presence of flavonoids, alkaloids, tannins, phenolics, and saponins, indicating antioxidant and hypoglycemic effects. Profiling using LC-HRMS found important chemicals such rutin (m/z 683.4), quercetin (m/z 303), procyanidin B2 (m/z 578), and ginsenoside Rb1 (m/z 1123.6), which are known to help with diabetes and have antioxidant properties. ADMET study showed that quercetin, rutin, and procyanidin B2 have good absorption, distribution, and low toxicity profiles. Molecular docking results demonstrated that quercetin showed strong binding affinities with α-glucosidase (−7.8 kcal/mol) and glucokinase (−8.0 kcal/mol); rutin exhibited high affinity toward α-amylase (−5.2 kcal/mol) and DPP-IV (−9.3 kcal/mol); and procyanidin B2 showed significant interactions with α-amylase (−5.1 kcal/mol) and DPP-IV (−9.1 kcal/mol). These strong binding interactions demonstrate that multiple targets are being inhibited in significant enzymes that control glucose levels. The results confirm the traditional Unani statements, confirming QZKH as a scientifically validated, safe, and efficacious antidiabetic formulation with robust multi-mechanistic activity using antioxidant, enzyme-inhibitory, and insulin-sensitizing pathways

Keywords: Qurs-e-Ziabetus Khas; Phytochemical profiling; Computational analysis; LC–HRMS; Diabetes mellitus; Unani medicine.

How to cite this article: Mounika K., Prasad PD. LC–HRMS, Molecular Docking, and ADMET-Based Evaluation of Qurs-e-Ziabetus Khas for Antidiabetic Potential. Int J Drug Deliv Technol. 2026;16(1): 97-122.

Source of support: Nil.

Conflict of interest: None

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